Forecasting residue-residue contact prediction accuracy

@article{Wozniak2017ForecastingRC,
  title={Forecasting residue-residue contact prediction accuracy},
  author={Pawel P. Wozniak and Bogumil Konopka and J. Xu and Gert Vriend and Malgorzata Kotulska},
  journal={Bioinformatics},
  year={2017},
  volume={33 21},
  pages={
          3405-3414
        }
}
Motivation Apart from meta-predictors, most of today's methods for residue-residue contact prediction are based entirely on Direct Coupling Analysis (DCA) of correlated mutations in multiple sequence alignments (MSAs). These methods are on average ∼40% correct for the 100 strongest predicted contacts in each protein. The end-user who works on a single… CONTINUE READING