Forecasting individual pharmacokinetics

  title={Forecasting individual pharmacokinetics},
  author={L. Sheiner and S. Beal and B. Rosenberg and V. V. Marathe},
  journal={Clinical Pharmacology & Therapeutics},
  • L. Sheiner, S. Beal, +1 author V. V. Marathe
  • Published 1979
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • Often drug dosage may be chosen rationally by use of plasma concentration (CP) as the “therapeutic” end point. The ability to accurately forecast the CP resulting from a dosage regimen is central to choosing that regimen. Traditionally forecasting has been attempted only by accounting for known influences on pharmacokinetics, such as sex, age, and renal disease. One must also adjust for previously observed CPs. Herein, we discuss and explain an approach to both of these tasks, mainly focusing… CONTINUE READING
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