Forecasting individual pharmacokinetics

@article{Sheiner1979ForecastingIP,
  title={Forecasting individual pharmacokinetics},
  author={L. Sheiner and S. Beal and B. Rosenberg and V. V. Marathe},
  journal={Clinical Pharmacology & Therapeutics},
  year={1979},
  volume={26}
}
  • L. Sheiner, S. Beal, +1 author V. V. Marathe
  • Published 1979
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • Often drug dosage may be chosen rationally by use of plasma concentration (CP) as the “therapeutic” end point. The ability to accurately forecast the CP resulting from a dosage regimen is central to choosing that regimen. Traditionally forecasting has been attempted only by accounting for known influences on pharmacokinetics, such as sex, age, and renal disease. One must also adjust for previously observed CPs. Herein, we discuss and explain an approach to both of these tasks, mainly focusing… CONTINUE READING
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    References

    SHOWING 1-10 OF 14 REFERENCES
    Modelling of individual pharmacokinetics for computer-aided drug dosage.
    • 369
    Individualization of phenytoin dosage regimens
    • 114
    The serum level approach to individualization of drug dosage
    • J. Koch-weser
    • Medicine
    • European Journal of Clinical Pharmacology
    • 2004
    • 39
    Optimal control analysis in the chemotherapy of IgG multiple myeloma.
    • 112
    Kuritzky P: Theophylline therapy: nomogram guidelines
    • Ann Intern Med
    • 1977
    Theophylline therapy: nomogram guidelines
    • Ann Intern Med
    • 1977
    dividualization of phenytoin dosage regimens
    • CUN PHARMACOL THER
    • 1977
    Digitalis assay and its clinical application.
    • S. Oparil
    • Medicine
    • The Medical clinics of North America
    • 1976
    • 9