Forebrain substrates of reward and motivation.

  • Roy Wise
  • Published 2005 in The Journal of comparative neurology


Electrical stimulation of the medial forebrain bundle can reward arbitrary acts or motivate biologically primitive, species-typical behaviors like feeding or copulation. The subsystems involved in these behaviors are only partially characterized, but they appear to transsynaptically activate the mesocorticolimbic dopamine system. Basal function of the… (More)


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