Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory.

@article{Chen2006ForebrainspecificKO,
  title={Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory.},
  author={Adele Pin Chen and Masuo Ohno and K Peter Giese and Ralf K{\"u}hn and Rachel Chen and Alcino J. Silva},
  journal={Journal of neuroscience research},
  year={2006},
  volume={83 1},
  pages={28-38}
}
Raf kinases are downstream effectors of Ras and upstream activators of the MEK-ERK cascade. Ras and MEK-ERK signaling play roles in learning and memory (L&M) and neural plasticity, but the roles of Raf kinases in L&M and plasticity are unclear. Among Raf isoforms, B-raf is preferentially expressed in the brain. To determine whether B-raf has a role in synaptic plasticity and L&M, we used the Cre-LoxP gene targeting system to derive forebrain excitatory neuron B-raf knockout mice. This… CONTINUE READING
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