Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury.

@article{Oyagi2011ForebrainSH,
  title={Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury.},
  author={Atsushi Oyagi and Nobutaka Morimoto and Junya Hamanaka and Mitsunori Ishiguro and Kazuhiro Tsuruma and Masamitsu Shimazawa and Hideaki Hara},
  journal={Neuroscience},
  year={2011},
  volume={185},
  pages={116-24}
}
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a hypoxia-inducible neuroprotective protein that also stimulates proliferation of neuronal precursor cells. In this study, we investigated the possible role of HB-EGF in ischemia and reperfusion injury by measuring the changes in its mRNA expression following focal cerebral ischemia. We also examined neural damage after a middle cerebral artery occlusion (MCAO) and reperfusion in ventral forebrain specific HB-EGF knockout… CONTINUE READING
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