Forebrain renin-angiotensin system has a tonic excitatory influence on renal sympathetic nerve activity.

@article{Wei2002ForebrainRS,
  title={Forebrain renin-angiotensin system has a tonic excitatory influence on renal sympathetic nerve activity.},
  author={S H Wei and Robert B Felder},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 3},
  pages={H890-5}
}
All elements of the renin-angiotensin system (RAS) are present in the forebrain, particularly in circumventricular organs surrounding the third cerebral ventricle. We tested the hypothesis that forebrain angiotensin-converting enzyme (ACE) has a tonic excitatory influence on sympathetic drive. Neurally intact and sinoaortic-denervated pentobarbital-anesthetized rats were treated with forebrain-directed intracarotid artery (ICA) versus intravenous injections of angiotensin I (ANG I) and of the… CONTINUE READING
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