Forebrain patterns of c‐Fos and FosB induction during cancer‐associated anorexia–cachexia in rat

@article{Konsman2005ForebrainPO,
  title={Forebrain patterns of c‐Fos and FosB induction during cancer‐associated anorexia–cachexia in rat},
  author={Jan Pieter Konsman and Anders Blomqvist},
  journal={European Journal of Neuroscience},
  year={2005},
  volume={21}
}
Forebrain structures are necessary for the initiation of food intake and its coupling to energy expenditure. The cancer‐related anorexia–cachexia syndrome is typified by a prolonged increase in metabolic rate resulting in body weight loss which, paradoxically, is accompanied by reduced food intake. The aim of the present work was to study the forebrain expression of Fos proteins as activation markers and thus to identify potential neurobiological mechanisms favouring catabolic processes or… 
Identification of rat brainstem neuronal structures activated during cancer‐induced anorexia
TLDR
Evidence is provided that cancer‐associated anorexia and weight loss in this model is associated with activation of brainstem circuits involved in the suppression of food intake, and that this occurs by inflammatory‐independent mechanisms.
Central and Peripheral Neuroendocrine Factors in Cancer-Associated Anorexia and Cachexia
TLDR
It appears that CARTp is not inducing anorexia in CACS, but seems to participate in an adaptive response, and hypothalamic nesfatin-1 may be a likely candidate for mediating a CACs response.
Proteomic profiling of the hypothalamus in a mouse model of cancer-induced anorexia-cachexia
TLDR
The identified differentially expressed proteins may be new candidate molecules involved in the pathophysiology of tumour-induced anorexia-cachexia, suggesting an involvement of these proteins in brain metabolic adaptation to restricted nutrient availability.
Brain response to induced peripheral cancer development in rats: dual fos-tyrosine hydroxylase and fos-oxytocin immunohistochemistry.
TLDR
The data obtained are supporting the view that the information on peripheral tumor development might be transmitted to the brain, and further studies are necessary to be performed to reveal whether the findings can be attributed to specific effect of cancer or whether observed changes in the activity of brainstem and hypothalamic neurons reflex processes that only accompany the cancer progression.
MCG101-induced cancer anorexia-cachexia features altered expression of hypothalamic Nucb2 and Cartpt and increased plasma levels of cocaine- and amphetamine-regulated transcript peptides.
The aim of the present study was to explore central and peripheral host responses to an anorexia-cachexia producing tumor. We focused on neuroendocrine anorexigenic signals in the hypothalamus,
Evidence of hypothalamic degeneration in the anorectic anx/anx mouse
TLDR
The hypothesis of degeneration of hypothalamic arcuate neuron populations in the anx/anx mice, whereby the AGRP system may be first affected, the changes in the POMC system being secondary in this process is supported.
Activity of Brain Stem Groups of Catecholaminergic Cells in Tumor‐Bearing Rats
TLDR
Investigating the activity of tyrosine hydroxylase (TH) immunopositive neurons, measured by Fos protein expression, in the hindbrain noradrenergic cell groups in animals exposed to visceral tumor growth for 28 days induced by intraperitoneal implantation of fibrosarcoma cells found increased Fos expression in NA cells in tumor‐bearing rats.
...
1
2
3
4
...

References

SHOWING 1-10 OF 88 REFERENCES
Activation of the central nervous system in obese Zucker rats during food deprivation
TLDR
It is demonstrated in the obese fa/fa Zucker rats, that food deprivation leads to brain activations, which are in large part, similar to those induced by a “neurogenic” stress and that the paraventricular thalamic nucleus is involved in this response.
Reversal of cancer anorexia by blockade of central melanocortin receptors in rats.
TLDR
Because SHU9119 completely reverses cancer anorexia in this model, whereas ghrelin and NPY do not, increased central nervous system melanocortin signaling is implicated in the pathogenesis of this disorder.
Chemical characterization of leptin‐activated neurons in the rat brain
TLDR
The results suggest that leptin stimulates brain pathways containing neuropeptides that are involved in the regulation of energy balance, autonomic homeostasis, and neuroendocrine status.
Role of the central melanocortin system in cachexia.
TLDR
It is demonstrated that cachexia induced by lipopolysaccharide administration and by tumor growth is ameliorated by central MC4-R blockade, providing further support for the potential role of MC 4-R antagonism in the treatment of cachexia in disease states.
Possible role of ammonia in experimental cancer anorexia
Distribution of fos‐like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration
TLDR
A significant sustained elevation of Fos‐like immunoreactivity was observed in a cell group adjacent to the organum vasculosum of the lamina terminalis, which is lead to hypothesize that the ventromedial preoptic area may be a key site for the initiation of fever during endotoxemia.
Induction of ΔFosB in Reward-Related Brain Structures after Chronic Stress
TLDR
It is established that chronic stress induces ΔFosB expression predominantly in the fCTX, NAc, and basolateral amygdala, with lower levels of induction seen elsewhere, which could contribute to the long-term effects of stress on the brain.
Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats.
  • D. McCarthy
  • Biology, Medicine
    Research in nursing & health
  • 1999
TLDR
The results of the present study suggest that PG synthesis is not a major factor in the onset of anorexia in this animal model of tumor-inducedAnorexia, and further studies of the effects of inhibitors of PG synthesis on the kinetics of tumor growth are clearly indicated.
Induction of deltaFosB in reward-related brain structures after chronic stress.
TLDR
It is established that chronic stress induces DeltaFosB expression predominantly in the fCTX, NAc, and basolateral amygdala, with lower levels of induction seen elsewhere, which could contribute to the long-term effects of stress on the brain.
Role of central melanocortins in endotoxin-induced anorexia.
TLDR
The results suggest that exogenous and endogenous melanocortins acting centrally exert divergent influences on different aspects of the acute phase response, suppressing LPS-induced fever but contributing to L PS-induced anorexia and hypoactivity.
...
1
2
3
4
5
...