Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia.

@article{Lai2007ForebrainMR,
  title={Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia.},
  author={Maggie Lai and Karen Horsburgh and S E Bae and Roderick N Carter and Dirk Jan Stenvers and Jill H. Fowler and Joyce L. W. Yau and Celso Enrique Gomez-Sanchez and M C Holmes and Christopher J. Kenyon and Jonathan R Seckl and Malcolm R. Macleod},
  journal={The European journal of neuroscience},
  year={2007},
  volume={25 6},
  pages={1832-42}
}
The nuclear mineralocorticoid receptor (MR), a high-affinity receptor for glucocorticoids, is highly expressed in the hippocampus where it underpins cognitive, behavioural and neuroendocrine regulation. Increased neuronal MR expression occurs early in the response to cellular injury in vivo and in vitro and is associated with enhanced neuronal survival. To determine whether increased neuronal MR might be causal in protecting against ischaemic damage in vivo we generated a forebrain-specific MR… CONTINUE READING