Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures

@inproceedings{Hellwig2015ForebrainMF,
  title={Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures},
  author={Sabine Hellwig and Annette Masuch and Sigrun Nestel and Natalie Katzmarski and Melanie Meyer-Luehmann and Knut Biber},
  booktitle={Scientific reports},
  year={2015}
}
The role of microglia in amyloid-β (Aβ) deposition is controversial. In the present study, an organotypic hippocampal slice culture (OHSC) system with an in vivo-like microglial-neuronal environment was used to investigate the potential contribution of microglia to Aβ plaque formation. We found that microglia ingested Aβ, thereby preventing plaque formation in OHSCs. Conversely, Aβ deposits formed rapidly in microglia-free wild-type slices. The capacity to prevent Aβ plaque formation was absent… CONTINUE READING