Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8.

@article{Blevins2009ForebrainMS,
  title={Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8.},
  author={James E. Blevins and Gregory J. Morton and Diana L. Williams and David W Caldwell and Lloyd S Bastian and Brent E. Wisse and Michael J. Schwartz and Denis G. Baskin},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2009},
  volume={296 3},
  pages={R476-84}
}
Melanocortin 4 receptors (MC4R) are hypothesized to mediate the central nervous system actions of leptin to enhance the satiety effects of cholecystokinin (CCK). To further elucidate this mechanism, we confirmed that peripheral administration of CCK-8 is less effective in producing this effect in MC4R-deficient mice (MC4R(-/-)). Whereas intraperitoneal (ip) CCK-8 at 0.75 nmol/kg lean body mass (lbm) suppressed food intake in wild-type mice, CCK-8 doses of 7.5 nmol/kg lbm were required to… CONTINUE READING

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