Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor

@article{Hartmann2017ForebrainGB,
  title={Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor},
  author={Jakob Hartmann and Nina Dedic and Max L. P{\"o}hlmann and Alexander S. H{\"a}usl and Henk Karst and Candace Engelhardt and S{\"o}ren Westerholz and Klaus V. Wagner and Christiana Labermaier and Lianne Hoeijmakers and M Kertokarijo and Aiguo Chen and Marian Jo{\"e}ls and Jan M. Deussing and Mathias V Schmidt},
  journal={Molecular Psychiatry},
  year={2017},
  volume={22},
  pages={466-475}
}
Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain open. Besides the involvement of the major excitatory (glutamate) and inhibitory (gamma aminobutyric acid (GABA)) neurotransmitter circuits in anxiety disorders, the stress system has been directly implicated in the pathophysiology of these complex mental illnesses. The glucocorticoid receptor (GR) is the major receptor for the stress… CONTINUE READING
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