Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

@article{Carln2009ForebrainEC,
  title={Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke},
  author={Marie Carl{\'e}n and Konstantinos Meletis and Christian G{\"o}ritz and Vladimer Darsalia and Emma Evergren and Kenji Tanigaki and Mario Amendola and Fanie Barnabé-Heider and Maggie S. Y. Yeung and Luigi Naldini and Tasuku Honjo and Zaal Kokaia and Oleg Shupliakov and R M Cassidy and Olle Lindvall and Jonas Fris{\'e}n},
  journal={Nature Neuroscience},
  year={2009},
  volume={12},
  pages={259-267}
}
Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contribute to adult neurogenesis under normal conditions in mice but instead gave rise to neuroblasts and astrocytes in response to stroke. Ependymal cell quiescence was actively maintained by canonical Notch signaling. Inhibition of this pathway in uninjured animals allowed ependymal cells to enter the cell… 
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TLDR
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