Corpus ID: 11830806

Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.

@article{Acampora1995ForebrainAM,
  title={Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.},
  author={D. Acampora and S. Mazan and Y. Lallemand and V. Avantaggiato and M. Maury and A. Simeone and P. Brûlet},
  journal={Development},
  year={1995},
  volume={121 10},
  pages={
          3279-90
        }
}
We have replaced part of the mouse homeogene Otx2 coding region with the E. coli lacZ coding sequence, thus creating a null allele of Otx2. By 9.5 dpc, homozygous mutant embryos are characterized by the absence of forebrain and midbrain regions. From the early to midstreak stages, endomesodermal cells expressing lacZ fail to be properly localized anteriorly. In the ectodermal layer, lacZ transcription is progressively extinguished, being barely detectable by the late streak stage. These data… Expand
Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR.
TLDR
Experimental evidence that murine brain development requires accurate translational control of Otx2 mRNA in epiblast and neuronal progenitor cells is provided, and it is hypothesized that this control might have important evolutionary implications. Expand
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Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.
TLDR
Results demonstrate that Otx2 is first required in the visceral endoderm for the induction, and subsequently in the neuroectodermfor the specification of forebrain and midbrain territories. Expand
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TLDR
Genetic evidence for a link between patterning of the anterior hindbrain and the establishment of the mid/hindbrain organizer is provided, and Gbx2 is identified as a gene required for these processes to occur normally. Expand
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TLDR
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Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.
TLDR
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otx2 expression in the ectoderm activates anterior neural determination and is required for Xenopus cement gland formation.
TLDR
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TLDR
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The expression domains of the four genes in the developing rostral brain of mouse embryos at a developmental stage, day 10 post coitum, seem to be continuous regions contained within each other in the sequence Emxl < Emx2 < Otxl< Otx2. Expand
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