Forebrain Ischemia Triggers GABAergic System Degeneration in Substantia Nigra at Chronic Stages in Rats

@inproceedings{Lin2010ForebrainIT,
  title={Forebrain Ischemia Triggers GABAergic System Degeneration in Substantia Nigra at Chronic Stages in Rats},
  author={Baowan Lin and Stanley B Levy and Ami P. Raval and Miguel A. P{\'e}rez-Pinz{\'o}n and Richard A DeFazio},
  booktitle={Cardiovascular psychiatry and neurology},
  year={2010}
}
The long-term consequences of forebrain ischemia include delayed Parkinson's syndrome. This study revealed delayed neurodegeneration in the substantia nigra 8 weeks after 12.5 minutes of global ischemia in rat brain. Following neuronal loss of 30-40% in central and dorsolateral striatum at day 3, neuronal damage in the substantia nigra (SN) was assessed at 4-8 weeks using immunohistochemistry for glutamate decarboxylase 67 (GAD67), vesicular GABA transporter (VGAT), and calretinin (CR). At day… CONTINUE READING