Forced retroevolution of an RNA bacteriophage.

@article{Licis2000ForcedRO,
  title={Forced retroevolution of an RNA bacteriophage.},
  author={Normunds Licis and Zita Balklava and Jan van Duin},
  journal={Virology},
  year={2000},
  volume={271 2},
  pages={298-306}
}
The operator hairpin ahead of the replicase gene in RNA bacteriophage MS2 contains overlapping signals for binding the coat protein and ribosomes. Coat protein binding inhibits further translation of the gene and forms the first step in capsid formation. The hairpin sequence was partially randomized to assess the importance of this structure element for the bacteriophage and to monitor alternative solutions that would evolve on the passaging of mutant phages. The evolutionary reconstruction of… CONTINUE READING
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