Forced expression of dystrophin deletion constructs reveals structure- function correlations

  title={Forced expression of dystrophin deletion constructs reveals structure- function correlations},
  author={J. A. S. Rafael and Gregory A. Cox and Kathleen Corrado and Dirk Jung and Kevin P Campbell and Jeffrey S. Chamberlain},
  journal={The Journal of Cell Biology},
  pages={93 - 102}
Dystrophin plays an important role in skeletal muscle by linking the cytoskeleton and the extracellular matrix. The amino terminus of dystrophin binds to actin and possibly other components of the subsarcolemmal cytoskeleton, while the carboxy terminus associates with a group of integral and peripheral membrane proteins and glycoproteins that are collectively known as the dystrophin-associated protein (DAP) complex. We have generated transgenic/mdx mice expressing "full-length" dystrophin… CONTINUE READING

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