Forced expression of chimeric human fibroblast tropomyosin mutants affects cytokinesis

  title={Forced expression of chimeric human fibroblast tropomyosin mutants affects cytokinesis},
  author={Kerri S. Warren and Jenny L-C Lin and Jeff P McDermott and Jim J.-C. Lin},
  journal={The Journal of Cell Biology},
  pages={697 - 708}
Human fibroblasts generate at least eight tropomyosin (TM) isoforms (hTM1, hTM2, hTM3, hTM4, hTM5, hTM5a, hTM5b, and hTMsm alpha) from four distinct genes, and we have previously demonstrated that bacterially produced chimera hTM5/3 exhibits an unusually high affinity for actin filaments and a loss of the salt dependence typical for TM-actin binding (Novy, R.E., J. R. Sellers, L.-F. Liu, and J.J.-C. Lin, 1993. Cell Motil. & Cytoskeleton. 26: 248-261). To examine the functional consequences of… CONTINUE READING


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