Forced expression of Nanog in hematopoietic stem cells results in a T-cell disorder

@inproceedings{Tanaka2007ForcedEO,
  title={Forced expression of Nanog in hematopoietic stem cells results in a T-cell disorder},
  author={Yosuke Tanaka and Takumi Era and Shin-ichi Nishikawa and Shin Kawamata},
  year={2007}
}
Nanog is a key molecule involved in the maintenance of the self-renewal of undifferentiated embryonic stem (ES) cells. In this work we investigate whether Nanog can enhance self-renewal in hematopoietic stem cells. Contrary to our expectation, no positive effect of Nanog transduction was detected in bone marrow reconstitution assays. However, recipients of… CONTINUE READING