Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells

@inproceedings{Stelcer2018ForcedDI,
  title={Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells},
  author={Ewelina Stelcer and Katarzyna Kulcenty and Marcin Rucinski and Karol Jopek and Magdalena Richter and Tomasz Trzeciak and Wiktoria Maria Suchorska},
  booktitle={PloS one},
  year={2018}
}
A human induced pluripotent stem cell line (GPCCi001-A) created by our group was differentiated towards chondrocyte-like cells (ChiPS) via monolayer culturing with growth factors. ChiPS are promising because they have the potential to be used in tissue engineering to regenerate articular cartilage. However, their safety must be confirmed before they can be routinely used in regenerative medicine. Using microarray analysis, we compared the ChiPS to both GPCCi001-A cells and chondrocytes. The… CONTINUE READING
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