Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine

@article{Tillerson2001ForcedLE,
  title={Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine},
  author={Jennifer L. Tillerson and Ann D. Cohen and Jeffry Philhower and Gary W. Miller and Michael J. Zigmond and Timothy J Schallert},
  journal={The Journal of Neuroscience},
  year={2001},
  volume={21},
  pages={4427 - 4435}
}
  • Jennifer L. Tillerson, Ann D. Cohen, +3 authors Timothy J Schallert
  • Published 2001
  • Biology, Medicine
  • The Journal of Neuroscience
  • Rats with unilateral depletion of striatal dopamine (DA) show marked preferential use of the ipsilateral forelimb. Previous studies have shown that implementation of motor therapy after stroke improves functional outcome (Taub et al., 1999). Thus, we have examined the impact of forced use of the impaired forelimb during or soon after unilateral exposure to the DA neurotoxin 6-hydroxydopamine (6-OHDA). In one group of animals, the nonimpaired forelimb was immobilized using a cast, which forced… CONTINUE READING

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