Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages.

@article{Zhao2016ForcedAO,
  title={Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages.},
  author={Junlong Zhao and Fei Huang and Fei He and Chun-chen Gao and Shi-qian Liang and Pengfei Ma and Guang-ying Dong and Hua Han and Hongyan Qin},
  journal={Cancer research},
  year={2016},
  volume={76 6},
  pages={
          1403-15
        }
}
Tumor-associated macrophages (TAM) contribute greatly to hallmarks of cancer. Notch blockade was shown to arrest TAM differentiation, but the precise role and underlying mechanisms require elucidation. In this study, we employed a transgenic mouse model in which the Notch1 intracellular domain (NIC) is activated conditionally to define the effects of active Notch1 signaling in macrophages. NIC overexpression had no effect on TAM differentiation, but it abrogated TAM function, leading to… 
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