Force transmission in migrating cells

  title={Force transmission in migrating cells},
  author={Maxime Fournier and Roger Sauser and D. Ambrosi and Jean-Jacques Meister and Alexander B. Verkhovsky},
  booktitle={The Journal of cell biology},
During cell migration, forces generated by the actin cytoskeleton are transmitted through adhesion complexes to the substrate. To investigate the mechanism of force generation and transmission, we analyzed the relationship between actin network velocity and traction forces at the substrate in a model system of persistently migrating fish epidermal keratocytes. Front and lateral sides of the cell exhibited much stronger coupling between actin motion and traction forces than the trailing cell… CONTINUE READING

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