Force spectroscopy of single DNA and RNA molecules.

@article{Williams2002ForceSO,
  title={Force spectroscopy of single DNA and RNA molecules.},
  author={Mark Campbell Williams and Ioulia Rouzina},
  journal={Current opinion in structural biology},
  year={2002},
  volume={12 3},
  pages={330-6}
}
Experiments in which single molecules of RNA and DNA are stretched, and the resulting force as a function of extension is measured have yielded new information about the physical, chemical and biological properties of these important molecules. The behavior of both single-stranded and double-stranded nucleic acids under changing solution conditions, such as ionic strength, pH and temperature, has been studied in detail. There has also been progress in using these techniques to study both the… CONTINUE READING

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