Force-induced formation and propagation of adhesion nanodomains in living fungal cells.

@article{Alsteens2010ForceinducedFA,
  title={Force-induced formation and propagation of adhesion nanodomains in living fungal cells.},
  author={David Alsteens and Melissa C. Garcia and Peter N Lipke and Yves F Dufr{\^e}ne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 48},
  pages={20744-9}
}
Understanding how cell adhesion proteins form adhesion domains is a key challenge in cell biology. Here, we use single-molecule atomic force microscopy (AFM) to demonstrate the force-induced formation and propagation of adhesion nanodomains in living fungal cells, focusing on the covalently anchored cell-wall protein Als5p from Candida albicans. We show that pulling on single adhesins with AFM tips terminated with specific antibodies triggers the formation of adhesion domains of 100-500 nm and… CONTINUE READING

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