Force-induced destabilization of focal adhesions at defined integrin spacings on nanostructured surfaces.

@article{Beer2010ForceinducedDO,
  title={Force-induced destabilization of focal adhesions at defined integrin spacings on nanostructured surfaces.},
  author={Alex G F de Beer and Elisabetta Ada Cavalcanti-Adam and G{\"u}nter Majer and Mart{\'i}n L{\'o}pez-Garc{\'i}a and Horst Kessler and Joachim P Spatz},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  year={2010},
  volume={81 5 Pt 1},
  pages={051914}
}
Focal adhesions are the anchoring points of cells to surfaces and are responsible for a large number of surface sensing processes. Nanopatterning studies have shown physiological changes in fibroblasts as a result of decreasing density of external binding ligands. The most striking of these changes is a decreased ability to form mature focal adhesions when… CONTINUE READING