Force generation by kinesin and myosin cytoskeletal motor proteins.

  title={Force generation by kinesin and myosin cytoskeletal motor proteins.},
  author={F Jon Kull and Sharyn Anne Endow},
  journal={Journal of cell science},
  volume={126 Pt 1},
Kinesins and myosins hydrolyze ATP, producing force that drives spindle assembly, vesicle transport and muscle contraction. How do motors do this? Here we discuss mechanisms of motor force transduction, based on their mechanochemical cycles and conformational changes observed in crystal structures. Distortion or twisting of the central β-sheet - proposed to trigger actin-induced Pi and ADP release by myosin, and microtubule-induced ADP release by kinesins - is shown in a movie depicting the… CONTINUE READING
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