Force-generating cross-bridges during ramp-shaped releases: evidence for a new structural state.

@article{Radocaj2009ForcegeneratingCD,
  title={Force-generating cross-bridges during ramp-shaped releases: evidence for a new structural state.},
  author={Ante Radocaj and Thomas Weiss and William I Helsby and Bernhard Brenner and Theresia Kraft},
  journal={Biophysical journal},
  year={2009},
  volume={96 4},
  pages={
          1430-46
        }
}
Mechanical and two-dimensional (2D) x-ray diffraction studies suggest that during isometric steady-state contraction, strongly bound cross-bridges mostly occupy early states in the power stroke, whereas rigor or rigor-like cross-bridges could not be detected. However, it remained unclear whether cross-bridges accumulate, at least transiently, in rigor or rigor-like states in response to rapid-length releases. We addressed this question using time-resolved recording of 2D x-ray diffraction… CONTINUE READING
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