Force-dependent switch in protein unfolding pathways and transition-state movements

  title={Force-dependent switch in protein unfolding pathways and transition-state movements},
  author={Pavel I Zhuravlev and Michael Hinczewski and Shaon Chakrabarti and Susan Marqusee and D. Thirumalai},
  journal={Proceedings of the National Academy of Sciences},
  pages={E715 - E724}
Significance Single-domain proteins with symmetrical arrangement of secondary structural elements in the native state are expected to fold by diverse pathways. However, understanding the origins of pathway diversity, and the experimental signatures for identifying it, are major challenges, especially for small proteins with no obvious symmetry in the folded states. We show rigorously that upward curvature in the logarithm of unfolding rates as a function of force (or denaturants) implies that… 

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