Force-dependent conformational switch of α-catenin controls vinculin binding.

@article{Yao2014ForcedependentCS,
  title={Force-dependent conformational switch of α-catenin controls vinculin binding.},
  author={Mingxi Yao and Wu Qiu and Ruchuan Liu and Artem K. Efremov and Peiwen Cong and Rima Seddiki and Manon Payre and Chwee Teck Lim and Beno{\^i}t Ladoux and Ren{\'e} Marc M{\`e}ge and Jie S. Yan},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={
          4525
        }
}
Force sensing at cadherin-mediated adhesions is critical for their proper function. α-Catenin, which links cadherins to actomyosin, has a crucial role in this mechanosensing process. It has been hypothesized that force promotes vinculin binding, although this has never been demonstrated. X-ray structure further suggests that α-catenin adopts a stable auto-inhibitory conformation that makes the vinculin-binding site inaccessible. Here, by stretching single α-catenin molecules using magnetic… CONTINUE READING
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