Force as a single molecule probe of multidimensional protein energy landscapes.

@article{oldk2013ForceAA,
  title={Force as a single molecule probe of multidimensional protein energy landscapes.},
  author={Gabriel Žold{\'a}k and Matthias Rief},
  journal={Current opinion in structural biology},
  year={2013},
  volume={23 1},
  pages={48-57}
}
Force spectroscopy has developed into an indispensable tool for studying folding and binding of proteins on a single molecule level in real time. Design of the pulling geometry allows tuning the reaction coordinate in a very precise manner. Many recent experiments have taken advantage of this possibility and have provided detailed insight the folding pathways on the complex high dimensional energy landscape. Beyond its potential to provide control over the reaction coordinate, force is also an… CONTINUE READING