Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae

@inproceedings{Sloboda2013ForceMD,
  title={Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae},
  author={Darc{\'e}e D. Sloboda and Dennis R. Claflin and James J Dowling and Susan V. Brooks},
  booktitle={Journal of visualized experiments : JoVE},
  year={2013}
}
Zebrafish larvae provide models of muscle development, muscle disease and muscle-related chemical toxicity, but related studies often lack functional measures of muscle health. In this video article, we demonstrate a method to measure force generation during contraction of zebrafish larval trunk muscle. Force measurements are accomplished by placing an anesthetized larva into a chamber filled with a salt solution. The anterior end of the larva is tied to a force transducer and the posterior end… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

Oxidative stress and successful antioxidant treatment in models of RYR 1 - related myopathy

J. J. Dowling, S. Arbogast
  • Brain .
  • 2012

Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy. Brain

J. J. Dowling, S Arbogast
  • 2012

Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of disease.

  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 2011

Drug screening in a zebrafish model of Duchenne muscular dystrophy.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011