Force Frequency Relationship of the Human Ventricle Increases During Early Postnatal Development

@article{Wiegerinck2009ForceFR,
  title={Force Frequency Relationship of the Human Ventricle Increases During Early Postnatal Development},
  author={R. Wiegerinck and Anca Cojoc and Carlo M Zeidenweber and Guoliang Ding and M. Shen and R. W. Joyner and Janet D. Fernandez and K. Kanter and P. Kirshbom and B. Kogon and M. Wagner},
  journal={Pediatric Research},
  year={2009},
  volume={65},
  pages={414-419}
}
Understanding developmental changes in contractility is critical to improving therapies for young cardiac patients. Isometric developed force was measured in human ventricular muscle strips from two age groups: newborns (<2 wk) and infants (3–14 mo) undergoing repair for congenital heart defects. Muscle strips were paced at several cycle lengths (CLs) to determine the force frequency response (FFR). Changes in Na/Ca exchanger (NCX), sarcoplasmic reticulum Ca-ATPase (SERCA), and phospholamban… Expand

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References

SHOWING 1-10 OF 47 REFERENCES
Effects of Postnatal Maturation on Myocardial Contractile Responses to Calcium Antagonists and Changes in Contraction Frequency
Gene expression of Na+/Ca2+ exchanger during development in human heart.
Force-frequency relationship in intact mammalian ventricular myocardium: physiological and pathophysiological relevance.
  • M. Endoh
  • Chemistry, Medicine
  • European journal of pharmacology
  • 2004
Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium.
Sarcoplasmic reticulum Ca(2+)ATPase and cell contraction in developing rabbit heart.
Developmental Regulation of the Sarcoplasmic Reticulum Calcium Pump in the Rabbit Heart
...
1
2
3
4
5
...