ForC lacks canonical formin activity but bundles actin filaments and is required for multicellular development of Dictyostelium cells.

Abstract

Diaphanous-related formins (DRFs) drive the nucleation and elongation of linear actin filaments downstream of Rho GTPase signalling pathways. Dictyostelium formin C (ForC) resembles a DRF, except that it lacks a genuine formin homology domain 1 (FH1), raising the questions whether or not ForC can nucleate and elongate actin filaments. We found that a… (More)
DOI: 10.1016/j.ejcb.2013.07.001

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