For the Long Run Maintaining Germinal Niches in the Adult Brain

  title={For the Long Run Maintaining Germinal Niches in the Adult Brain},
  author={Arturo Alvarez-Buylla and Daniel A. Lim},
The adult mammalian brain retains neural stem cells that continually generate new neurons within two restricted regions: the subventricular zone (SVZ) of the lateral ventricle and the dentate gyrus subgranular zone (SGZ) of the hippocampus. Though these cellular populations are spatially isolated and subserve different brain systems, common themes begin to define adult neurogenic niches: (1) astrocytes serve as both stem cell and niche cell, (2) a basal lamina and concomitant vasculogenesis may… CONTINUE READING
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