For better or for worse.

  title={For better or for worse.},
  author={Titia de Lange and Tyler Jacks},
  journal={Journal of the Royal Naval Medical Service},
  volume={77 3},
  • T. Lange, T. Jacks
  • Published 1991
  • Medicine
  • Journal of the Royal Naval Medical Service
embryonic stem (ES) cells (as well as the numerous tools Over the past several years, the scientific and popular available for studying tumor development in the mouse), press has been bubbling over with experimental findings there are two important differences between mice and that would seem to be setting the stage for a magic humans regarding telomeres and telomerase regulation. bullet against cancer. The focus of this fervor is the First, telomerase activity is less stringently repressed in… Expand
Immortalized Mammary Epithelial Cell Line Growth Factor Requirements and Basal Phenotype of an Updated
Carcinogenesis involves a multistep process whereby a normal healthy cell undergoes both immortalization and oncogenesis to become fully transformed. Immortalization results from the subversion ofExpand
Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.
Evidence is presented that the overexpression of human telomerase reverse transcriptase was sufficient to extend the life span of the cells and allow for additional events that lead to immortalization, and that the immortalization of basal epithelial cells of the mammary gland may be an early step in the initiation of a subset of breast cancers with a basal epithelium phenotype. Expand
Activation of p53 protein by telomeric (TTAGGG)n repeats.
It is found that the introduction of a TR into cells leads to stabilization of the p53 protein, which was specific to TRs and was not observed in response to exposure of cells to plasmids containing non-TR sequences. Expand
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
Understanding the functional crosstalk between BRCA1–BARD1 and its cofactors and antagonists will illuminate the molecular basis of cancers that arise from a deficiency or misregulation of chromosome damage repair and replication fork maintenance. Expand
Elimination of Senescent Cells: Prospects According to the Subtelomere-Telomere Theory
Positive effects of the elimination of senescent cells and limits of this method are discussed, as well of the combined action of the two methods and the possible association of opportune gene modifications, and ethical issues associated with the use of these methods are outlined. Expand
Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences
The contribution of BER to genomic integrity in the context of immune receptor diversification, cancer and autoimmune diseases is discussed. Expand
Autophagy Correlates with Maintenance of Salivary Gland Function Following Radiation
Autophagy appears to play a beneficial role in salivary glands following radiation and pharmacological induction of autophagy could alleviate the negative side effects associated with therapy for head and neck cancer. Expand
Replication of G Quadruplex DNA
The circumstances in which DNA forms secondary structures, the potential responses of the eukaryotic replisome to these impediments in the light of recent advances in understanding of its structure and operation and the mechanisms cells deploy to remove secondary structure from the DNA are considered. Expand
CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy
The results indicate that CPT1C-mediated autophagy enhancement in glucose deprivation conditions allows a greater availability of lipids to be used as fuel substrate for ATP generation, revealing a new role of C PT1C in stem cell adaptation to low nutrient environments. Expand
Aging, defined as “increasing mortality with increas- ing chronological age in populations in the wild” [1], also known as “actuarial senescence in the wild” [2], or “pro- gressive loss of function accompanied by decreasing fer-
The programmed aging paradigm interprets aging as a function favored by natural selection at a supra-individual level. This function is implemented, according to the telomere theory, throughExpand