Footstrike is the major cause of hemolysis during running.

@article{Telford2003FootstrikeIT,
  title={Footstrike is the major cause of hemolysis during running.},
  author={Richard D. Telford and G. Jr. Sly and Allan G. Hahn and Ross B. Cunningham and C Bryant and John Abernathy Smith},
  journal={Journal of applied physiology},
  year={2003},
  volume={94 1},
  pages={
          38-42
        }
}
There is a wide body of literature reporting red cell hemolysis as occurring after various forms of exercise. Whereas the trauma associated with footstrike is thought to be the major cause of hemolysis after running, its significance compared with hemolysis that results from other circulatory stresses on the red blood cell has not been thoroughly addressed. To investigate the significance of footstrike, we measured the degree of hemolysis after 1 h of running. To control for the potential… Expand
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Foot-strike haemolysis after a 60-km ultramarathon.
TLDR
This is the first study demonstrating that long-distance running does not induce clinically significant changes in haemoglobin, haematocrit, RBC count or potassium concentration, and indicates that the foot-strike haemolysis is very modest or even clinically negligible. Expand
Epidemiological, biological and clinical update on exercise-induced hemolysis.
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Additional lines of evidence support the notion that both osmotic fragility and membrane structure of erythrocytes are considerably modified during endurance exercise, and it seems also reasonable to hypothesize that patients bearing ERYthrocyte disorders may be particularly vulnerable to developing exercise-induced hemolysis. Expand
Intravascular hemolysis and mean red blood cell age in athletes.
TLDR
Investigation of aerobic performance, hematological parameters, serum erythropoietin concentration (EPO), soluble transferrin receptor concentration (sTFR), and erythrocyte aspartate aminotransferase activity found mechanisms other than foot-strike hemolysis have to be considered as well. Expand
Hemolysis induced by an extreme mountain ultra‐marathon is not associated with a decrease in total red blood cell volume
TLDR
The findings indicate that mechanical/physiological stress associated with RUN promotes hemolysis but this has no impact on total erythrocyte volume, and it is suggested that exercise ‘anemia’ is entirely due to plasma volume expansion and not to a concomitant decrease in RCV. Expand
Beneficial effects of the whole-body cryotherapy on sport haemolysis
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WBC reduces sports haemolysis, as judged from MSCV and haptoglobin data, supported from other haematological values, as well as the absence of mean corpuscolar volume and reticulocytes increase. Expand
Early changes of the anemia phenomenon in male 100‐km ultramarathoners
TLDR
Running a 100‐km ultramarathon will induce substantial sports anemia, and oxidative stress response, hemolysis, hematuria, and gastrointestinal bleeding are typical factors that contribute to its onset. Expand
Sports as a cause of oxidative stress and hemolysis.
TLDR
The association between chronic exercise and impairment in erythrocytes number and form is clearer, and recent information opens discussion about whether hemolytic etiology is a co adjuvant factor to anemia, and on the role of oxidative stress in it. Expand
Haemodynamics during cycling and long-distance running: a clue to footstrike haemolysis in Indian athletes.
TLDR
The results indicate that intravascular haemolysis occurred significantly during running when compared with cycling, and it is concluded that the mechanical trauma due to footstrike is the major cause of intrav vascular haemsolysis during running. Expand
Exercise hemorheology: classical data, recent findings and unresolved issues.
TLDR
The data published on the effects of exercise on the hemorheological profile of healthy individuals and patients with cardiovascular and metabolic disorders are not consistent, with some studies showing decreased, unchanged, or increased red blood cell deformability/aggregation when compared with rest. Expand
Haemolysis caused by alterations of α- and β-spectrin after 10 to 35 min of severe exercise
The pathophysiology of exercise related haemolysis is not thoroughly understood. We investigated whether exercise related haemolysis (1) is associated with alterations of red blood cell (RBC)… Expand
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References

SHOWING 1-10 OF 32 REFERENCES
Foot impact force and intravascular hemolysis during distance running.
TLDR
Findings support the theory that mechanical trauma to red blood cells occurring at footstrike is a major cause of hemolysis during running. Expand
Exercise, Training and Red Blood Cell Turnover
TLDR
Because most techniques examine the RBC population as a whole, more sophisticated methods which analyse cells individually are required to determine the mechanisms involved in exercise-induced damage of RBCs. Expand
Endurance swimming, intravascular hemolysis, anemia, and iron depletion. New perspective on athlete's anemia.
TLDR
Iron depletion, anemia, and intravascular hemolysis in athletes in a nontraumatic sport suggest that mechanisms other than footstrike are components of athlete's hemolytic disease. Expand
Effect of shoe cushioning on the development of reticulocytosis in distance runners
TLDR
The positive correlation between per cent reticulocytes and Peak g suggests that shoe rear foot cushioning is one determinant of the erythropoietic response to increased training mileage in distance runners. Expand
Training-dependent changes of red cell density and erythrocytic oxygen transport.
TLDR
The decreased Hb-O2 affinity after training can be explained by the presence of more young erythrocytes in the blood of trained subjects, and the magnitude of this effect correlates with the training status. Expand
Vascular volumes and hematology in male and female runners and cyclists
TLDR
A role for the vascular system in realizing a high aerobic power in trained athletes is suggested and foot-strike hemolysis would not appear to have an effect on that parameter. Expand
Response of red cell and plasma volume to prolonged training in humans.
TLDR
To clarify the role of progressive heavy training on vascular volumes and hematologic status, seven untrained males cycled 2 h/day at an estimated 62% of VO2max for approximately 8 wk. Expand
Hemolysis during triathlon races: its relation to race distance.
TLDR
Data from two different length triathlons suggest that nearly all triathletes break down red blood cells during a race, and that the extent of the hemolysis is related to race distance. Expand
Sex, sport, and body-size dependency of hematology in highly trained athletes.
TLDR
The data indicate that the rationality of interpreting the hematology in highly trained athletes may be increased by taking BMI and sport into account, as well as gender. Expand
Concise review: methemoglobinemia.
TLDR
In hereditary cytochrome b5 deficiency, treatment is often directed at improving the poor cosmetic effect of persistent cyanosis with the minimum amount of drugs to give satisfactory clinical results. Expand
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