Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome

  title={Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome},
  author={Lydia Hopp and Henry Loeffler-Wirth and Lilit Nersisyan and Arsen Arakelyan and Hans Binder},
  journal={Frontiers in Immunology},
We analyzed the blood transcriptome of sepsis framed within community-acquired pneumonia (CAP) and characterized its molecular and cellular heterogeneity in terms of functional modules of co-regulated genes with impact for the underlying pathophysiological mechanisms. Our results showed that CAP severity is associated with immune suppression owing to T-cell exhaustion and HLA and chemokine receptor deactivation, endotoxin tolerance, macrophage polarization, and metabolic conversion from… 
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