Footprints of Optimal Protein Assembly Strategies in the Operonic Structure of Prokaryotes

@inproceedings{Ewald2015FootprintsOO,
  title={Footprints of Optimal Protein Assembly Strategies in the Operonic Structure of Prokaryotes},
  author={Jan Ewald and Martin K{\"o}tzing and Martin Bartl and Christoph Kaleta and Ines Heiland},
  booktitle={Metabolites},
  year={2015}
}
In this work, we investigate optimality principles behind synthesis strategies for protein complexes using a dynamic optimization approach. We show that the cellular capacity of protein synthesis has a strong influence on optimal synthesis strategies reaching from a simultaneous to a sequential synthesis of the subunits of a protein complex. Sequential synthesis is preferred if protein synthesis is strongly limited, whereas a simultaneous synthesis is optimal in situations with a high protein… CONTINUE READING
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