Footprint fears for new TB threat

  title={Footprint fears for new TB threat},
  author={Nigel Williams},
  journal={Current Biology},
  • N. Williams
  • Published 10 October 2006
  • Biology
  • Current Biology
New research suggests that the significance of TB for the prevalence of cystic fibrosis mutations in European populations may have been overlooked as fears grow over the threat from aggressive new drug-resistant strains. Nigel Williams reports. 
Hypothesis: Possible respiratory advantages for heterozygote carriers of cystic fibrosis linked mutations during dusty climate of last glaciation.
The proposed interpretation is that CFTR mutations have spread among the authors' ancestors that roamed the central Eurasia after the LGM, and the heterozygote individuals might have benefitted from the limited water resorption in their respiratory mucosa that allowed improved airway cleansing.
Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatis
34 novel small RNAs (sRNAs) are found in the TB-complex M. bovis BCG, using a combination of experimental and computational approaches, and various features and regulatory aspects of some of these sRNAs are discussed.