Foot and mouth disease (FMD) virus: quantification of whole virus particles during the vaccine manufacturing process by size exclusion chromatography.

@article{Spitteler2011FootAM,
  title={Foot and mouth disease (FMD) virus: quantification of whole virus particles during the vaccine manufacturing process by size exclusion chromatography.},
  author={Marcelo A Spitteler and Ignacio Fern{\'a}ndez and Erika Schabes and Alejandro Krimer and Emmanuel G. R{\'e}gulier and Mariela Guinzburg and Eliana Smitsaart and Myriam Susana Levy},
  journal={Vaccine},
  year={2011},
  volume={29 41},
  pages={7182-7}
}
Foot and mouth disease (FMD) is a highly infectious viral disease that affects cattle, sheep, goats and swine causing severe economic losses worldwide. The efficacy of inactivated vaccines is critically dependent on the integrity of foot and mouth disease virus (FMDV) particles. The recommended method to quantify the active ingredient of vaccines is the 140S quantitative sucrose density gradient analysis. This method has been an immensely valuable tool over the past three decades but it is… CONTINUE READING