Food reward: Orexin-signaling in ventral tegmental area contributes to high-fat intake induced by accumbens opioid stimulation.

@article{Zheng2007FoodRO,
  title={Food reward: Orexin-signaling in ventral tegmental area contributes to high-fat intake induced by accumbens opioid stimulation.},
  author={Huiyuan Zheng and Laurel M. Patterson and Hans-R. Berthoud},
  journal={Appetite},
  year={2007},
  volume={49}
}
The nucleus accumbens in the ventral striatum is considered a pivotal structure in food reward and addictive behavior. Injection of the mu-opioid agonist DAMGO into this structure powerfully stimulates intake of preferred palatable foods such as high fat, but the downstream neural mechanisms are not well understood. We have previously shown that accumbens-hypothalamic projections and orexin-signaling are important since ICV administration of the selective orexin receptor antagonist SB334768… CONTINUE READING
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