Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography.

Abstract

INTRODUCTION Dopamine (DA) regulates food intake by modulating food reward and motivation but its involvement in obesity is much less understood. Recent evidence points to the involvement of leptin in the DA-related modulation of food intake. Here we assess DA D2 receptors (D2R) in a genetic rodent obesity model characterized by leptin-receptor deficiency… (More)

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@article{Thanos2008FoodRM, title={Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography.}, author={Panayotis K. Thanos and Michael Michaelides and Yiannis K Piyis and Gene-Jack Wang and Nora D. Volkow}, journal={Synapse}, year={2008}, volume={62 1}, pages={50-61} }