Food intolerance and chronic constipation: manometry and histology study

  title={Food intolerance and chronic constipation: manometry and histology study},
  author={Giuseppe Iacono and Sebastiano Bonventre and Calogero Scalici and Emiliano Maresi and Lidia Di Prima and Maurizio Soresi and Giuseppe Di Ges{\`u} and Davide Noto and Antonio Carroccio},
  journal={European Journal of Gastroenterology \& Hepatology},
Background Chronic constipation in children can be caused by cows' milk intolerance (CMI), but its pathogenesis is unknown. Aims To evaluate the histology and manometry pattern in patients with food intolerance-related constipation. Patients and methods Thirty-six consecutive children with chronic constipation were enrolled. All underwent an elimination diet and successive double-blind food challenge. All underwent rectal biopsy and anorectal manometry. Results A total of 14 patients were found… 

Constipation and Cow's Milk Allergy: A Review of the Literature

It is believed that a CM-free diet for 2-4 weeks should be proposed for children with chronic functional constipation, even if it is not severe or resistant to laxatives.

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In children with food allergy-related chronic constipation, an increase in both rectal MC density and spatial interactions between MCs and NFs correlates with anal motor abnormalities.

Colonic lymphoid nodular hyperplasia in children: relationship to food hypersensitivity.

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  • 2007

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Cows’ Milk Allergy-Associated Constipation: When to Look for It? A Narrative Review

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Anorectal manometric profile in patients presenting with chronic constipation associated with a mobile cecum

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It is found that the Gastrointestinal tract (GIT) scintigraphic transit study or “nuclear transit study” (NTS) has been effective in characterizing a variety of dysfunctional patterns of colonic transit, and dietary exclusion in these children normalized stool consistency and improved abdominal pain and pain on defecation.



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Food intolerance-related constipation is characterized by proctitis with eosinophil infiltrate of the rectal mucosa, and a reduced mucus gel layer can be considered a contributory factor in the pathogenesis of the constipation.

Cow's milk protein intolerance and chronic constipation in children

  • S. DaherS. Tahan M. B. de Morais
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2001
It is suggested that CMP allergy or intolerance should be considered as a cause of chronic refractory constipation in children, although the underlying mechanism still require further investigation.

Constipation in children.

Anorectal manometric studies have been performed in normal infants and children and in children with significant constipation, and there appears to be a proportionate relationship between the volume of rectal distention and the amplitude of relaxation and contraction of the anal sphincteric components.

Gastroesophageal reflux associated with cow's milk allergy in infants: which diagnostic examinations are useful?

Evidence of a characteristic pattern of the pH-monitoring tracing and of a high IgG anti-beta-lactoglobulin value are specific and sensitive tests for GER + CMPA diagnosis are concluded.

Vomiting and Gastric Motility in Infants With Cow's Milk Allergy

In sensitized infants, cow's milk induces severe gastric dysrhythmia and delayed gastric emptying, which in turn may exacerbate gastroesophageal reflux and induce reflex vomiting.

Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial

Food elimination based on IgG antibodies may be effective in reducing IBS symptoms and is worthy of further biomedical research.

Mucin depletion in inflammatory bowel disease.

The results suggest that it is worth while assessing the mucin content of rectal biopsy specimens from patients with inflammatory bowel disease to consider the gland content, which can be made by eye using a suitably stained section.

Altered expression of mucins throughout the colon in ulcerative colitis.

BACKGROUND/AIMS: Regional differences in the biology of the colonic epithelium may determine the extent of involvement by ulcerative colitis. Novel monoclonal antibodies (MAbs) were used in this

IgG anti-betalactoglobulin (betalactotest): its usefulness in the diagnosis of cow's milk allergy.

It is suggested that the betalactotest should be used to confirm diagnosis in patients with suspected CMPA; with a cut-off of over 48% the authors found only one false positive for diagnosis of CMPA in patients presenting other diseases with an identical clinical picture.