Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.

@article{Jonghe2012FoodIR,
  title={Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.},
  author={Bart C De Jonghe and Matthew R Hayes and Derek J Zimmer and Scott E. Kanoski and Harvey J. Grill and Kendra K. Bence},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={303 5},
  pages={
          E644-51
        }
}
Leptin regulates energy balance through central circuits that control food intake and energy expenditure, including proopiomelanocortin (POMC) neurons. POMC neuron-specific deletion of protein tyrosine phosphatase 1B (PTP1B) (Ptpn1(loxP/loxP) POMC-Cre), a negative regulator of CNS leptin signaling, results in resistance to diet-induced obesity and improved peripheral leptin sensitivity in mice, thus establishing PTP1B as an important component of POMC neuron regulation of energy balance. POMC… CONTINUE READING

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