Food intake is inhibited by oral oleoylethanolamide.

  title={Food intake is inhibited by oral oleoylethanolamide.},
  author={Mie Julin Nielsen and Gitte Petersen and A. -S. Astrup and Harald S Hansen},
  journal={Journal of lipid research},
  volume={45 6},
Oleoylethanolamide (OEA) may be an endogenous regulator of food intake, and intraperitoneal injection of this compound decreases food intake in 24 h-starved rats. It is generally believed that this kind of lipid amide is rapidly catabolized in the gastrointestinal tract, thereby preventing its use as an oral antiobesity compound. We now show that oral OEA inhibits food intake dose dependently at 90 min after food presentation to starved rats. Food intake was reduced by 15.5% (P < 0.01) by… CONTINUE READING


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