Food-induced increase in propranolol bioavailability--relationship to protein and effects on metabolites.

@article{Walle1981FoodinducedII,
  title={Food-induced increase in propranolol bioavailability--relationship to protein and effects on metabolites.},
  author={Thomas Walle and Timothy C Fagan and U. Kristina Walle and Mary Joan Oexmann and E C Conradi and Tim Gaffney},
  journal={Clinical pharmacology and therapeutics},
  year={1981},
  volume={30 6},
  pages={790-5}
}
The influence of a meal on the disposition and metabolism of oral propranolol was examined in six normal subjects. The meal induced a mean 53% increase in propranolol bioavailability (range 2% to 92%; P less than 0.01) without affecting time to maximum concentration, half-life, or the amount of unchanges drug in urine. There was no effect on the plasma concentrations of 4-hydroxypropranolol or four other metabolites. The increased bioavailability was linearly related to the protein content of… CONTINUE READING