Food-induced "dose-dumping" from a once-a-day theophylline product as a cause of theophylline toxicity.

@article{Hendeles1985FoodinducedF,
  title={Food-induced "dose-dumping" from a once-a-day theophylline product as a cause of theophylline toxicity.},
  author={Leslie Hendeles and Miles Weinberger and Gary Milavetz and Malcolm R. Hill and Lee Vaughan},
  journal={Chest},
  year={1985},
  volume={87 6},
  pages={
          758-65
        }
}
Three slow-release preparations of theophylline have received approval from the U.S. Food and Drug Administration (FDA) for "once-daily" dosing indications, amid controversy regarding the appropriateness of this decision. Because of specific concerns regarding data submitted to the FDA in support of the first of these products to be approved, Theo-24, we examined the absorption characteristics of this newly marketed formulation. Eight healthy volunteers received, in a crossover manner, single… Expand
The clinical significance of food-induced changes in the absorption of theophylline from Uniphyl tablets.
TLDR
There was no evidence of "dose dumping" after either food or fasting administration of Uniphyl, and there was no significant difference in the maximum theophylline concentration attained between the two dosing conditions. Expand
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Food interactions with once-a-day theophylline preparations: a review.
  • J. Jonkman
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  • Chronobiology international
  • 1987
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Information about food interaction with once-a-day theophylline preparations is reviewed as this topic is important both for clinicians as well as those concerned with chronopharmacologic investigations of such medications. Expand
Food induced changes in theophylline absorption from a once-a-day theophylline product.
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It is concluded that children should not take SRT in large doses in combination with food and that food caused a substantial change in the absorption pattern of theophylline so that the profiles became rather unpredictable with delays in absorption and periods of rapidly increasing serum drug concentrations. Expand
The Effect of Food on the Absorption of Controlled-Release Theophylline in Mini-Swine
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The effect of differing fat contents of food on the bioavailability of theophylline following a 400-mg single dose of Theo-24 was studied in mini-swine and appeared to have decreased the rate of absorption but no significant effect on the extent of absorption. Expand
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TLDR
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A review is given of those food interactions with the sustained-release theophylline preparations, both twice-daily and once-daily products, that are currently on the world market. Expand
Selection of a slow-release theophylline product.
Slow-release formulations of theophylline, if absorbed completely, consistently, and at a sufficiently slow rate, provide more stable serum concentrations at longer dosing intervals than plainExpand
Effects of food on the absorption of theophylline in children.
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  • Medicine
  • The Journal of allergy and clinical immunology
  • 1986
TLDR
It is concluded that the in vivo performance of sustained-release theophylline formulations in combination with food cannot be predicted on the results from absorption studies in fasting patients or from in vitro dissolution tests. Expand
Relationship between rate and extent of absorption of oral theophylline from Uniphyl brand of slow-release theophylline and resulting serum concentrations during multiple dosing.
TLDR
Characterization of rate and extent of absorption from single doses permit prediction of the mean serum concentration-time profile during multiple dosing at defined rates of theophylline elimination, which provides the potential to anticipate fluctuations in serum concentrations at clinically relevant elimination rates that deviate from the mean of samples typically used for study. Expand
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