Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex.

@article{Karteris2005FoodDD,
  title={Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex.},
  author={Emmanou{\'i}l Karteris and Rachel J Machado and Jing Chen and Sevasti Zervou and Edward W. Hillhouse and Harpal Randeva},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={288 6},
  pages={E1089-100}
}
Although starvation-induced biochemical and metabolic changes are perceived by the hypothalamus, the adrenal gland plays a key role in the integration of metabolic activity and energy balance, implicating feeding as a major synchronizer of rhythms in the hypothalamic-pituitary-adrenal (HPA) axis. Given that orexins are involved in regulating food intake and activating the HPA axis, we hypothesized that food deprivation, an acute challenge to the systems that regulate energy balance, should… CONTINUE READING

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