Food-dependent Cushing's syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells.

@article{Herder1996FooddependentCS,
  title={Food-dependent Cushing's syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells.},
  author={Wouter W de Herder and Leo J. Hofland and Ted B Usdin and Frank H. de Jong and Piet Uitterlinden and Peter V van Koetsveld and Esteban Mezey and Tom I. Bonner and H Jaap Bonjer and Steven W. J. Lamberts},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 9},
  pages={
          3168-72
        }
}
We studied a 45-yr-old woman with food-dependent Cushing's syndrome. Plasma cortisol levels were subnormal (4-47 nmol/L) after an overnight fast and increased after a mixed meal to values between 500-1000 nmol/L. There was a close correlation between circulating gastric inhibitory polypeptide (GIP) and cortisol levels during normal food intake (r = 0.92; P < 0.0002). Plasma corticotropin (ACTH) levels were undetectable. Nonfasting plasma cortisol levels were not suppressed by low or high doses… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…