Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
@article{Sze2000FoodAM, title={Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant}, author={J. Y. Sze and M. Victor and C. Loer and Y. Shi and G. Ruvkun}, journal={Nature}, year={2000}, volume={403}, pages={560-564} }
The functions of serotonin have been assigned through serotonin-receptor-specific drugs and mutants; however, because a constellation of receptors remains when a single receptor subtype is inhibited, the coordinate responses to modulation of serotonin levels may be missed. Here we report the analysis of behavioural and neuroendocrine defects caused by a complete lack of serotonin signalling. Analysis of the C. elegans genome sequence showed that there is a single tryptophan hydroxylase gene… CONTINUE READING
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