Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant

  title={Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant},
  author={Ji Y. Sze and Martin Victor and Curtis M. Loer and Yang Shi and Gary Ruvkun},
The functions of serotonin have been assigned through serotonin-receptor-specific drugs and mutants; however, because a constellation of receptors remains when a single receptor subtype is inhibited, the coordinate responses to modulation of serotonin levels may be missed. Here we report the analysis of behavioural and neuroendocrine defects caused by a complete lack of serotonin signalling. Analysis of the C. elegans genome sequence showed that there is a single tryptophan hydroxylase gene… 
Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity
This study investigates a variety of mutations in serotonin‐signal genes, including serotonin biosynthesis genes, a serotonin transporter gene, and serotonin receptor genes, and suggests that serotonin signal antagonistically modulates longevity through different serotonin receptors.
Receptors and Other Signaling Proteins Required for Serotonin Control of Locomotion in Caenorhabditis elegans
Serotonin functions as an extrasynaptic signal that independently activates multiple receptors at a distance from its release sites and at least six additional proteins that appear to act with serotonin receptors to mediate serotonin response are identified.
Tryptophan hydroxylase (TRH) loss of function mutations in Daphnia deregulated growth, energetic, serotoninergic and arachidonic acid metabolic signalling pathways
Serotonin has a pivotal function regulating development, growth, reproduction and behavior in animals. In this paper, we studied the deregulatory effects of the deprivation of serotonin in Daphnia
Deficiency in RCAT-1 Function Causes Dopamine Metabolism Related Behavioral Disorders in Caenorhabditis elegans
The discovery of rcat-1 not only identifies a new subtype of dopamine-related behaviors but also provides a potential therapeutic target in Parkinson’s disease.
The regulation of feeding and metabolism in response to food deprivation in Caenorhabditis elegans
There is a rationale to support the argument that an understanding of the molecular and genetic basis of feeding and fat regulation in C. elegans may contribute to efforts aimed at the identification of targets for the treatment of conditions associated with abnormal metabolism and obesity.
Global Transcriptome Changes That Accompany Alterations in Serotonin Levels in Caenorhabditis elegans
These studies are the first to catalog systemic transcriptome changes that occur upon alterations in 5-HT levels and show that in C. elegans changes in gene expression upon altering 5- HT levels, and changes in physiology, are not directly correlated.
Function and evolution of the serotonin-synthetic bas-1 gene and other aromatic amino acid decarboxylase genes in Caenorhabditis
The bas-1 gene of C. elegans encodes a serotonin- and dopamine-synthetic AADC enzyme, which raises questions about how many 'predicted genes' in sequenced genomes are functional, and how duplicate genes are retained or lost during evolution.
Mutations in the Caenorhabditis elegans Serotonin Reuptake Transporter MOD-5 Reveal Serotonin-Dependent and -Independent Activities of Fluoxetine
Analysis of the MOD-5-independent behavioral effects of fluoxetine could lead to the identification of novel targets of fluxetine and could facilitate the development of more specific human pharmaceuticals.
Serotonin signaling in C. elegans
The enhanced slowing response defect of flp-i is primarily due to its defect in transmitting a 5-HT signal and thatflp- i likely acts downstream of ser-4 and mod-1, and the genetic analysis suggests that ser4 acts in a pathway with goa- 1, in parallel to mod-5.


The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
It is shown that null mutations in Daf-16 suppress the effects of mutations in daf-2 or age-1; lack of dAF-16 bypasses the need for this insulin receptor-like signalling pathway.
Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans.
Using a new assay that allows measurement of pumping rate in a population of worms suspended in liquid by measuring their uptake of microscopic iron particles, it is demonstrated that starvation stimulates pumping and a role for acetylcholine in the regulation of pumping is suggested.
The genetics of caloric restriction in Caenorhabditis elegans.
  • B. Lakowski, S. Hekimi
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
It is demonstrated that food restriction lengthens life span by a mechanism distinct from that of dauer-formation mutants, and it is found thatFood restriction does not further increase the life span of long-lived clk-1 mutants, suggesting that clK-1 and caloric restriction affect similar processes.
The cat-1 Gene of Caenorhabditis elegansEncodes a Vesicular Monoamine Transporter Required for Specific Monoamine-Dependent Behaviors
It appears that the function of amine neurotransmitters can be completely dependent on their loading into synaptic vesicles.
Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans
The results suggest that dominant egl-2 mutations activate an inhibitory dopaminergic pathway that can be blocked by tricyclics and D2 antagonists, and it is found that these drugs stimulate egg laying in mutants lacking 5-HT or the HSN neurons, consistent with a target on the egg-laying muscles.
The genetics of feeding in Caenorhabditis elegans.
The pharynx of Caenorhabditis elegans is a nearly self-contained neuromuscular organ responsible for feeding, and screening for worms with visible defects in pharyngeal feeding behavior identified 35 genes involved in the development or function of the excitable cells of thepharynx, at least 22 previously unknown.
Two neuronal G proteins are involved in chemosensation of the Caenorhabditis elegans Dauer-inducing pheromone.
It is shown here that two novel G protein alpha subunits (GPA-2 and GPA-3) show promoter activity in subsets of chemosensory neurons and are involved in the decision to form dauer larvae primarily through the response to dauer pheromone.
Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.
The strengths of the Daf-c, Age, and Itt phenotypes largely correlated with each other but not with the strength of class 2-specific defects, which suggests that the DAF-2 receptor is bifunctional.