Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant

@article{Sze2000FoodAM,
  title={Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant},
  author={Ji Y. Sze and Martin Victor and Curtis M. Loer and Yang Shi and Gary Ruvkun},
  journal={Nature},
  year={2000},
  volume={403},
  pages={560-564}
}
The functions of serotonin have been assigned through serotonin-receptor-specific drugs and mutants; however, because a constellation of receptors remains when a single receptor subtype is inhibited, the coordinate responses to modulation of serotonin levels may be missed. Here we report the analysis of behavioural and neuroendocrine defects caused by a complete lack of serotonin signalling. Analysis of the C. elegans genome sequence showed that there is a single tryptophan hydroxylase gene… 
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References

SHOWING 1-10 OF 70 REFERENCES
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
TLDR
It is shown that null mutations in Daf-16 suppress the effects of mutations in daf-2 or age-1; lack of dAF-16 bypasses the need for this insulin receptor-like signalling pathway.
Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans.
TLDR
Using a new assay that allows measurement of pumping rate in a population of worms suspended in liquid by measuring their uptake of microscopic iron particles, it is demonstrated that starvation stimulates pumping and a role for acetylcholine in the regulation of pumping is suggested.
The genetics of caloric restriction in Caenorhabditis elegans.
  • B. Lakowski, S. Hekimi
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
TLDR
It is demonstrated that food restriction lengthens life span by a mechanism distinct from that of dauer-formation mutants, and it is found thatFood restriction does not further increase the life span of long-lived clk-1 mutants, suggesting that clK-1 and caloric restriction affect similar processes.
The cat-1 Gene of Caenorhabditis elegansEncodes a Vesicular Monoamine Transporter Required for Specific Monoamine-Dependent Behaviors
TLDR
It appears that the function of amine neurotransmitters can be completely dependent on their loading into synaptic vesicles.
Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans
TLDR
The results suggest that dominant egl-2 mutations activate an inhibitory dopaminergic pathway that can be blocked by tricyclics and D2 antagonists, and it is found that these drugs stimulate egg laying in mutants lacking 5-HT or the HSN neurons, consistent with a target on the egg-laying muscles.
The genetics of feeding in Caenorhabditis elegans.
TLDR
The pharynx of Caenorhabditis elegans is a nearly self-contained neuromuscular organ responsible for feeding, and screening for worms with visible defects in pharyngeal feeding behavior identified 35 genes involved in the development or function of the excitable cells of thepharynx, at least 22 previously unknown.
Two neuronal G proteins are involved in chemosensation of the Caenorhabditis elegans Dauer-inducing pheromone.
TLDR
It is shown here that two novel G protein alpha subunits (GPA-2 and GPA-3) show promoter activity in subsets of chemosensory neurons and are involved in the decision to form dauer larvae primarily through the response to dauer pheromone.
Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.
TLDR
The strengths of the Daf-c, Age, and Itt phenotypes largely correlated with each other but not with the strength of class 2-specific defects, which suggests that the DAF-2 receptor is bifunctional.
...
1
2
3
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...