• DOI:10.1038/35000609
Corpus ID: 4394553

Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant

@article{Sze2000FoodAM,
  title={Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant},
  author={J. Y. Sze and M. Victor and C. Loer and Y. Shi and G. Ruvkun},
  journal={Nature},
  year={2000},
  volume={403},
  pages={560-564}
}

J. Y. Sze, M. Victor, +2 authors G. Ruvkun

Published 2000

Biology, Medicine

Nature

The functions of serotonin have been assigned through serotonin-receptor-specific drugs and mutants; however, because a constellation of receptors remains when a single receptor subtype is inhibited, the coordinate responses to modulation of serotonin levels may be missed. Here we report the analysis of behavioural and neuroendocrine defects caused by a complete lack of serotonin signalling. Analysis of the C. elegans genome sequence showed that there is a single tryptophan hydroxylase gene… CONTINUE READING

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